Biotechnology is changing remarkably with the introduction of organ-on-a-chip models. These are miniature but functional organs that replicate the conditions of human organs, giving invaluable insight into disease mechanisms, drug testing, and personalized medicine. An important part of the development and success of these models is high-quality cell culture media. Out of several components, charcoal-stripped FBS (Fetal Bovine Serum) has been a vital improvement to the growth and function of cells in these systems.
What is Charcoal Stripped FBS?
Charcoal-stripped fetal bovine serum (FBS) is a specialized serum that depletes particular hormones, growth factors, other bioactive molecules, and contaminants through charcoal filtration. Because of these factors, using charcoal-stripped fetal bovine serum makes experimental designs attempting to study control behaviors in cell models more applicable to understanding beyond an environment’s interference. Applying charcoal-stripped serum provides clear behavioral deciphering by removing any outside interference from the cell stimuli or drugs being tested.
Importance in Organ-on-a-Chip Development
Conditions simulating an organ-on-a-chip must be created for cellular behavior modeling. Charcoal-stripped FBS offers highly defined cell culture conditions in which unexpected interactions between natural components of the serum and the model system can be eliminated. Such purity and fidelity would allow a more controlled and reproducible study of cellular responses to outside factors such as pharmaceuticals or toxins.
Also, serum that has been charcoaled helps the cells to proliferate and mature into more specific and functional types, which is important for the construction of multi-organ models in organ-on-chip systems that imitate human diseases and therapeutic outcomes.
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The charcoal-stripped serum is proving to be an increasingly vital tool in the move toward developing organ-on-chip models, while accurate and human-relevant research has been in demand. In addition, providing a defined, serum-free environment for cell cultures will help the researchers create more advanced and reliable organ models for basic research or even clinical applications.
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